Immunology School Listings Home            

   Immunology Schools Feedback Feedback

Immunology Schools Feedback
ImmunologySchool Listings
Immunology Careers
Free Course on Immunology
Immunology Schools Examination
Immunology Schools FAQs
Anatomy Top Schools/School Rankings
Anatomy Top Schools/School Rankings

Campylobacter


ORGANISM:

  • Genus: Campylobacter
  • Species: jejuni


GENERAL CONCEPTS:
  • The genus Campylobacter is a relatively recently discovered important human pathogen. The reason for this is that the organisms are microaerophilic, requiring low concentrations of oxygen only. Indeed, Campylobacter infections occur more often than Salmonella and Shigella diarrheas combined. In the United States, there are about 2 million cases annually, most among college students.


DISTINCTIVE PROPERTIES:
  • Campylobacters are Gram-negative, curved rods (the name derives from the Greek "campylo", meaning curved). These organisms are microaerophilic and motile.
  • Campylobacters possess a typical Gram-negative cell wall containing LPS endotoxin.
  • There are approximately 50 heat-labile "K" (capsular) and "H" (flagellar) antigens and 60 different heat-stable "O" (somatic) antigens associated with different species of Campylobacter.
  • These organisms are able to use amino acids and citric acid cycle intermediates for growth. C. jejuni grows best at 42.


PATHOGENESIS:
  • A relatively small inoculum is required to cause illness; as few as 800 bacteria can produce disease in healthy persons.
  • Illness generally occurs following a 2-4 day incubation period when the bacteria multiply in the intestine, reaching numbers similar to Salmonella and Shigella infections (106-109 per gram of feces). Symptoms resemble an acute enteritis with fever, diarrhea, nausea and abdominal pain. The illness is generally self-limiting but may last a week.
  • C. jejuni appears to produce an enterotoxin similar to both the cholera and Escherichia coli toxins.


HOST DEFENSES:
  • Host defense mechanisms that help to combat Campylobacter infections are not well characterized but gastric acidity and secretory IgA may be important.


EPIDEMIOLOGY:
  • The genus Campylobacter is widely distributed among cattle, sheep, dogs, cats and other animals, existing as normal flora commensals.
  • Human infection results from the ingestion of contaminated water, milk or undercooked foods. Outbreaks resulting from ingestion of raw clams have been reported.


DIAGNOSIS:

  • Clinical: Clinical diagnosis is difficult since the symptomology is non-specific.
  • Laboratory: Special methods are required for isolation. Growth occurs in 5% O2, 10% CO2, 85% N2 at 42. A Gram stain of fecal material may reveal curved ("seagull" or "comma") shaped organisms.


CONTROL:

  • Sanitary: As with other fecal-oral diseases, sanitary means of control are most important. Proper disposal of feces, cooking foods, etc. can prevent disease.
  • Immunological: None available.
  • Chemotherapeutic: Erythromycin or tetracycline can be used for severe or prolonged illness.

Our Network Of Sites:
Apply 4 Admissions.com               | A2ZColleges.com  | OpenLearningWorld.com  | Totaram.com
Anatomy Colleges.com                 | Anesthesiology Schools.com  | Architecture Colleges.com | Audiology Schools.com
Cardiology Colleges.com            | Computer Science Colleges.com | Computer Science Schools.com | Dermatology Schools.com
Epidemiology Schools.com          | Gastroenterology Schools.com  | Hematology Schools.com     | Immunology Schools.com
IT Colleges.com                | Kinesiology Schools.com  | Language Colleges.com  | Music Colleges.com
Nephrology Schools.com             | Neurology Schools.com  | Neurosurgery Schools.com | Obstetrics Schools.com
Oncology Schools.com    | Ophthalmology Schools.com | Orthopedics Schools.com       | Osteopathy Schools.com
Otolaryngology Schools.com | Pathology Schools.com  | Pediatrics Schools.com   | Physical Therapy Colleges.com
Plastic Surgery Schools.com | Podiatry Schools.com   | Psychiatry Schools.com   | Pulmonary Schools.com 
Radiology Schools.com | Sports Medicine Schools.com | Surgery Schools.com  | Toxicology Schools.com
US Law Colleges.com | US Med Schools.com | US Dental Schools.com

Copyright 2000-2011 Immunology Schools, All Right Reserved. | Site Map | Privacy Policy | Disclaimer